منابع مشابه
Platinum nanoparticles induce damage to DNA and inhibit DNA replication
Sparsely tested group of platinum nanoparticles (PtNPs) may have a comparable effect as complex platinum compounds. The aim of this study was to observe the effect of PtNPs in in vitro amplification of DNA fragment of phage λ, on the bacterial cultures (Staphylococcus aureus), human foreskin fibroblasts and erythrocytes. In vitro synthesized PtNPs were characterized by dynamic light scattering ...
متن کاملEngineered Nanoparticles Induce DNA Damage in Primary Human Skin Cells, Even at Low Doses
It is well documented that various particulate matter — either incidental or engineered — are known to generate reactive oxygen species (ROS) in living cells. In circumstances where these reactive species are generated, antioxidant production is often increased. This balance in the biological reduction/oxidation (a.k.a. redox) state within the cell has not been thoroughly studied in exposures i...
متن کاملTitanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice.
Titanium dioxide (TiO(2)) nanoparticles are manufactured worldwide in large quantities for use in a wide range of applications including pigment and cosmetic manufacturing. Although TiO(2) is chemically inert, TiO(2) nanoparticles can cause negative health effects, such as respiratory tract cancer in rats. However, the mechanisms involved in TiO(2)-induced genotoxicity and carcinogenicity have ...
متن کاملWeakly charged cationic nanoparticles induce DNA bending and strand separation.
Weakly charged cationic nanoparticles cause structural changes including local denaturing and compaction to DNA under mild conditions. The charged ligands bind to the phosphate backbone of DNA and the uncharged ligands penetrate the helix and disrupt base pairing. Mobility shifts in electrophoresis, molecular dynamics, and UV-vis spectrophotometry give clues to the details of the interactions.
متن کاملOccupational Noise Exposure May Induce Oxidative DNA Damage
Occupational noise enhances the risk of several cardiovascular and non-cardiovascular diseases. The reason behind the drastic effects of noise exposure is the excessive generation of reactive oxygen species molecules. The present study investigates oxidative stress due to occupational noise exposure in 192 male smoking workers exposed to normal noise (sound level ≤80 dBA), low noise (sound leve...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Materials Today
سال: 2012
ISSN: 1369-7021
DOI: 10.1016/s1369-7021(12)70103-7